Publications
68.T. M. Campbell, S. Finzel, H. Siddle, R. Christensen, S. M. Nielsen, A. Najm, T. M. Otobo, I. Sahbudin, P. Sinnathurai, K. S. Stok, Z. Touma, K. Toupin April, S. Grosskleg, P. Tugwell, B. Richards, Navigating the Path of Progress: the OMERACT 2023 Emerging Leaders Program, Seminars in Arthritis and Rheumatism, 152414, https://doi.org/10.1016/j.semarthrit.2024.152414, 2024.
67.T. Nie, V. S. Venkatesh, S. Golub, K. S. Stok, H. Hemmatian, R. Desai, D. J. Handelsman, J. D. Zajac, M. Grossmann, R. A. Davey, Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender affirming hormone therapy, Bone Reports, 12 (1), https://doi.org/10.1038/s41413-023-00308-2, 2024.
66.J. E. Schadow, D. Maxey, T. O. Smith, M. A. J. Finnilä, S. L. Manske, N. A. Segal, A. K. O. Wong, R. A. Davey, T. Turmezei, K. S. Stok, Systematic review of computed tomography parameters used for the assessment of subchondral bone in osteoarthritis, Bone, 178:116948, doi:10.1016/j.bone.2023.116948, 2024.
65.Y. Al-Khoury, S. Finzel, A. J. Burghardt, K. S. Stok, L-S. Tam, J. J. Tse, S. L. Manske on behalf of the SPECTRA Collaboration, Erosion identification in the metacarpophalangeal joints in rheumatoid arthritis using high-resolution peripheral quantitative computed tomography, J Vis Exp., 200: 65802, doi:10.3791/65802, 2023.
64.H. Liu, P. Durongbhan, C. E. Davey, K. S. Stok, Image registration in longitudinal bone assessment using computed tomography, (invited review), Curr Osteoporos Rep, 21:372–385, doi:10.1007/s11914-023-00795-6, 2023.
63.M. A. Boos, F. A. Ryan, F. Linnenschmidt, M. S. B. Rathnayake, C. J. Nowell, S. R. Lamandé, K. S. Stok, A novel device for investigating structure-function relationships and mechanoadaptation of biological tissues, J Mech Behav Biomed Mater, 105868, doi:10.1016/j.jmbbm.2023.105868, 2023.
62.V. Sharma, J. A. Adegoke, I. Afara, K. Stok, C. Gassner, E. Poon, G. Starkey, R. D'Costa, F. James, C. Gordon, B. Wood, J. Raman, Near-infrared spectroscopy for structural bone assessment: a potential point-of-care tool, The Bone Jt Open, 4(4):251-60, doi:10.1302/2633-1462.44.BJO-2023-0014.R1, 2023.
61.S. R. Lamandé, E. Ng, T. L. Cameron, L. H. W. Kung, L. Sampurno, L. Rowley, J. Lilianty, Y. N. Patria, T. Stenta, E. Hanssen, K. M. Bell, R. Saxina, K. S. Stok, E. G. Stanley, A. G. Elefanty, J. F. Bateman, Modeling human skeletal development using human pluripotent stem cells, PNAS, 120 (19) e2211510120, https://doi.org/10.1073/pnas.2211510120, 2023.
60.P. Durongbhan, J. W. MacKay, J. E. Schadow, C. E. Davey, K. S. Stok, Quantitative morphometric analysis in tibiofemoral joint osteoarthritis imaging: a literature review, Osteoarthritis Imaging, 3(1):100088, https://doi.org/10.1016/j.ostima.2023.100088, 2023.
59.U. Heilmeier, A. J. Burghardt, J. J. Tse, P. Kapoor, K. S. Stok, S. Manske, R. E. Voll, G, Schett, S. Finzel, Analysis of hand joint space morphology in women and men with hereditary hemochromatosis, Calcified Tissue International, 112:440-451, https://doi.org/10.1007/s00223-022-01050-3, 2023.
58.P. Durongbhan, M. O. Silva, Z. Li, N. Ansari, R. Y. N. Kour, C. E. Davey, K. S. Stok, A microCT imaging protocol for reproducible and efficient quantitative morphometric analysis (QMA) of joint structures for in situ mouse tibio-femoral joint, Bone, 166:116606, https://doi.org/10.1016/j.bone.2022.116606, 2023.
57.M. Oliveira Silva, N. Kirkwood, P. Mulvaney, A. V. Ellis, K. S. Stok, Evaluation of a lanthanide nanoparticle-based contrast agent attenuation in sintered porous channel capillaries and mouse subchondral bone with micro-computed tomography, J. Orthop Res, 41:447-458, https://doi.org/10.1002/jor.25361, 2023.
56.M. Zhao, J. J. Tse, M. T. Kuczynski, S. C. Brunet, R. Yan, K. Engelke, M. Peters, J. P. van den Bergh, B. van Rietbergen, K. S. Stok, C. Barnabe, Y. Pauchard, S. L. Manske, Open-source image analysis tool for the identification and quantification of cortical interruptions and bone erosions in high-resolution peripheral quantitative computed tomography images of patients with rheumatoid arthritis, Bone, 165:116571, https://doi.org/10.1016/j.bone.2022.116571, 2022.
55.P. Durongbhan, C. E. Davey, K. S. Stok, A SPHARM-PDM based image preprocessing pipeline for robust quantitative morphometric analysis (QMA) for in situ joint assessment in rabbit and rat models, Part of the Collection: “Improving reproducibility in animal research”. Sci Rep, 12:1113, https://doi.org/10.1038/s41598-021-04542-8, 2022.
54.M. A. Boos, S. R. Lamandé, K. S. Stok, Multiscale strain transfer in cartilage, Frontiers in Cell and Developmental Biology, 10: 795522, doi: 10.3389/fcell.2022.795522, 2022.
53. L. Lam, G. Yau, C. Brandl, L. A. Johnston, and K. S. Stok, Improving learning through technology-enhanced dynamic and interactive engineering content, 2:1050-1058, 9th Research in Engineering Education Symposium and 32nd Australasian Association for Engineering Education Conference: Engineering Education Research Capability Development, 2021.
52.M. A. Boos, M. W. Grinstaff, S. R. Lamandé, K. S. Stok, Contrast-enhanced micro-computed tomography for 3D visualisation and quantification of glycosaminoglycans in different cartilage types, Cartilage, 13(Suppl 2): 486S–494S, doi: 10.1177/19476035211053820, 2021.
51. M. S. B. Rathnayake, B. Farrugia, K. Kulakova, C. E. M. ter Voert, G. J. V. M. van Osch, K. S. Stok, Macromolecular interactions in cartilage extracellular matrix vary according to the cartilage type and location, Cartilage, 2021, DOI: 10.1177/19476035211000811.
50. B. A. Besler, J. E. Schadow, P. Durongbhan, T. H. Steiner, R. J. Choo, M. A. Zulliger, M. Wilke, K. Atal, C. Firminger, A. Quintin, B. Koller, R. Müller, D. Nesic and K. S. Stok, Quantitative measures of bone shape, cartilage morphometry and joint alignment are associated with disease in an ACLT and MMx rat model of osteoarthritis, Bone, 146, 2021, 115903. DOI: 10.1016/j.bone.2021.115903.
49. S. Finzel, C. Barnabe, A. J. Burghardt, H. Marotte, A. Scharmga, E-M. Hauge, S. Kraus, S. Boutroy, R. Charpulat, K. Engelke, X. Li, B. van Teeffelen, P. G. Conaghan, K. S. Stok on behalf of SPECTRA (Study grouP for xtrEme Computed Tomography in Rheumatoid Arthritis), Detection and Measurement of Erosions by High-Resolution peripheral quantitative Computed Tomography (HR-pQCT) in a Longitudinal Dataset of Rheumatoid Arthritis Patients using the SPECTRA-Definition for Erosion: RELIABILITY EXERCISE-2 (RELEX-2), J. Rheum, 48(3):348–351, 2021, jrheum.191391.
48. M. Oliveira Silva, J. L. Gregory, N. Ansari, K. S. Stok, Molecular signalling interactions and transport at the osteochondral interface: a review, Frontiers in Cell and Developmental Biology, 8:750, 2020. DOI: 10.3389/fcell.2020.00750
47. C. E. M. ter Voert, N. R. Y. Kour, B. van Teeffelen, N. Ansari, K. S. Stok, Contrast-enhanced micro-computed tomography of articular cartilage morphology with ioversol and iomeprol, J. Anat, 237(6):1062–71, 2020, DOI: 10.1111/joa.13271.
46. R. Klose-Jensen, J. J. Tse, K. Krarup Keller, C. Barnabe, A. J. Burghardt, S. Finzel, L. S. Tam, E. M Hauge, K. S. Stok, S. L. Manske, High-resolution peripheral quantitative computed tomography for bone evaluation in inflammatory rheumatic disease (Invited Review), Frontiers in Medicine, 7:337, 2020.
45. K. S. Stok, A. J. Burghardt, S. Boutroy, M. P. H. Peters, S. Manske, V. Stadelmann, N. Vilayphiou, J. van den Bergh, P. Geusens, X. Li, H. Marotte, B. van Rietbergen, S. K. Boyd, C. Barnabe for the SPECTRA Collaboration, A consensus approach to determining joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high resolution peripheral quantitative computed tomography (HR-pQCT), QIMS, 10(2), 2020.
44. J. Lehmann, S. Nürnberger, R. Narcisi, K. S. Stok, B. C. J. van der Eerden, W J.L.M. Koevoet, N. Kops, D. ten Berge, G.J. van Osch, Recellularization of auricular cartilage via elastase-generated channels, Biofabrication, 11(3):035012, 2019.
43. C. A. Flurey, P. S. Tugwell, R. J. Black, S. Halls, M. J. Page, J. C. Robson, I. Sahbudin, H. Siddle, P. Sinnathurai, K. S. Stok, B. Richards, The OMERACT Emerging Leaders program: The good, the bad and the future, J. Rheum, 46(8):1047–52, 2019.
42. C. Mattei, R. Lim, H. Drury, B. Nasr, Z. Li, G. M. D’Abaco, K. S. Stok, B. A. Nayagam and M. Dottori. Generation of vestibular tissue-like organoids from human pluripotent stem cells using the rotary cell culture system, Frontiers in Cell and Developmental Biology, 7:25, 2019.
41. S. L. Manske, S. C. Brunet, S. F. Finzel, K. S. Stok, P. G. Conaghan, S. K. Boyd, C. Barnabe. The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High Resolution peripheral Quantitative Computed Tomography (HR-pQCT), J. Rheum, 46(10):1369–73, 2019.
40. M. Peters, J. de Jong, A. Scharmga, A. van Tubergen, P. Geusens, D. Loeffen, R. Weijers, S.K. Boyd, C. Barnabe, K. S. Stok, B. van Rietbergen, J. van den Bergh. An automated algorithm for the detection of cortical interruptions and its underlying loss of trabecular bone; a reproducibility study, BMC Medical Imaging, 18:13, 2018.
39. M. M. Pleumeekers, L. Nimeskern, W. L. M. Koevoet, N. Kops, M. Karperien, K. S. Stok, G. J. V. M. van Osch, Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture, PLoS One, 13(2):e0190744, 2018.
38. K. S. Stok, S. Finzel, A. J. Burghardt, P. G. Conaghan, C. Barnabe. The SPECTRA Collaboration (Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis) OMERACT Special Interest Group – Current Research and Future Directions, J Rheum, 44, 2017.
37. S. Tom, M. Frayne, S. L. Manske, A. J. Burghardt, K. S. Stok, S. K. Boyd, and C. Barnabe, Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT), J Rheum, 43:1941–44, 2016.
36. C. Barnabe, D. Toepfer, H. Marotte, E.M. Hauge, A. Scharmga, R. Kocijan, S. Kraus, S. Boutroy, K. Karup Keller, J. de Jong, J. Williams, K. S. Stok, S. Finzel, Definition for Rheumatoid Arthritis Erosions Imaged with High Resolution Peripheral Quantitative Computed Tomography and Inter-Reader Reliability for Detection and Measurement, J Rheum, 43:1935–40, 2016.
35. S. Nagaraj, S. Finzel, K.S. Stok, C. Barnabe and the SPECTRA Collaboration, High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) Imaging in the Assessment of Periarticular Bone of Metacarpophalangeal and Wrist Joints, J Rheum, 43:1921–34, 2016.
34. J. Walser, K.S. Stok, M.D. Caversaccio, and S.J. Ferguson. Direct electrospinning of 3D auricle-shaped scaffolds for tissue engineering applications, Biofabrication, 8(2):025007, 2016.
33. K. S. Stok, B. A. Besler, T. H. Steiner, A. V. Villarreal Escudero, M. A. Zulliger, M. Wilke, K. Atal, A. Quintin, B. Koller, R. Müller and D. Nesic. Three-dimensional quantitative morphometric analysis (QMA) for in situ joint and tissue assessment of osteoarthritis in a preclinical rabbit disease model, PLoS One, 11(1): e0147564, 2016.
32. L. Nimeskern, L. Utomo, I. Lehtoviita, G. Fessel, J. G. Snedeker, G. J.V.M van Osch, R. Müller, K. S. Stok, Tissue composition regulates distinct viscoelastic responses in auricular and articular cartilage, J. Biomech, 49(3):344-352, 2016.
31. B. A. Lakin, H. Patel, C. Holland, J. D. Freedman, J. S. Shelofsky, B. D. Snyder, M. W. Grinstaff and K. S. Stok. Contrast-enhanced CT using a cationic contrast agent enables non-destructive assessment of the biochemical and biomechanical properties of mouse tibial plateau cartilage, J. Orthop Res, 34(7):1130–1138, 2016.
30. B. A. Besler, R. E. Sondergaard, R. Müller and K. S. Stok, Reproducibility of compartmental subchondral bone morphometry in the mouse tibiofemoral joint, Bone, 81(12):649–653, 2015.
29. L. Nimeskern, M. M. Pleumeekers, D. J. Pawson, W. L. M. Koevoet, I. Lehtoviita, M. B. Soyka, C. Röösli, D. Holzmann, G. J. V. M. van Osch, R. Müller and K. S. Stok. Mechanical and biochemical mapping of human auricular cartilage for reliable assessment of tissue-engineered constructs, J Biomech, 48(10): 1721–1729, 2015.
28. M. M. Pleumeekers, L. Nimeskern, W. L. M. Koevoet, M. Karperien, K. S. Stok and G. J. V. M. van Osch. Cartilage regeneration in the head and neck area: Combination of ear or nasal chondrocytes and mesenchymal stem cells improves cartilage production, Plast Reconstr Surg, 136(6): 762e–74e, 2015.
27. D. J. Pawson, M. Glanzmann, R. Lüchinger, R. Müller, K. S. Stok, Quantitative morphometric patterns in cartilage and bone from the humeral heads of end-stage osteoarthritis patients. Osteoarthr Cartilage, 23:1377–1387, 2015.
26. N. M. Kogan, E. Melamed, E. Wasserman, B. Raphael, A. Breuer, K. S. Stok, R. Sondergaard, A. V. Villarreal Escudero, S. Baraghithy, M. Attar-Namdar, S. Friedlander-Barenboim, N. Mathavan, H. Isaksson, R. Mechoulam, R. Müller, A. Bajayo, Y. Gabet and I. Bab, Cannabidiol, a major non-psychotrophic cannabis constituent enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts, JBMR, 30(10):1905–1913, 2015.
25. C. Barnabe, S. Finzel, K. S. Stok, P. Geusens, Invited correspondence “High-resolution peripheral quantitative CT in rheumatology”, Nature Rev Rheum, 11(2):123, 2015.
24. H. Martínez Ávila, E. Feldmann, M. M. Pleumeekers, L. Nimeskern, W. Kuo, W. C. de Jong, S. Schwarz, R. Müller, J. Hendriks, N. Rotter, G.J.V.M. van Osch, K. S. Stok and P. Gatenholm, Novel bilayer bacterial nanocellulose scaffold supports neocartilage formation in vitro and in vivo. Biomaterials, 44:122–133, 2015.
23. L. Utomo, M. M. Pleumeekers, L. Nimeskern, S. Nürnberger, K. S. Stok, F. Hildner, G. J.V.M. van Osch, Processing and characterization of a decellularized cartilage scaffold for ear cartilage reconstruction, Biomedical Materials, 10(1), 015010, 2015.
22. L. Nimeskern, N. Rotter, G.J.V.M van Osch, R. Müller and K. S. Stok, Response to Letter to the Editor Concerning, “Quantitative evaluation of mechanical properties in tissue-engineered auricular cartilage”, Tissue Eng Part B Rev. 21(2): 244–245, 2015.
21. L. Nimeskern, E. M. Feldmann, S. Schwarz, W. Kuo, S. Duerr, E. Goldberg-Bockhorn, R. Müller, N. Rotter, K. S. Stok, Magnetic Resonance Imaging of the ear for patient-specific reconstructive surgery, PLoS One, 9(8): e104975, 2014.
20. M.M. Pleumeekers, L. Nimeskern, W.L.M. Koevoet, N. Kops, R.M.L. Poublon, K. S. Stok, G.J.V.M. van Osch, The in vitro and in vivo capacity of culture-expanded human cells from several sources encapsulated in alginate to form cartilage. Eur. Cells. Mater, 27:265–280, 2014.
19. L. Nimeskern, G.J.V.M van Osch, R. Müller and K. S. Stok. Quantitative evaluation of mechanical properties in tissue-engineered auricular cartilage. Tissue Eng. Part B Rev., 20(1):17–27, 2014.
18. F. Rikhtegar, C. Wyss, K. S. Stok, D. Poulikakos, R. Müller and V. Kurtcuoglu. Hemodynamics in coronary arteries with overlapping stents. J. Biomech., 47(1):505–511, 2014.
17. S. Hofmann, K. S. Stok, T. Kohler, A. J. Meinel, and R. Müller. Sterilization effects on structure and properties of 3D silk fibroin scaffolds, Acta Biomat., 10(1):308–317, 2014.
16. R. J. Choo, R. Müller and K. S. Stok. Prevention of cartilage dehydration in imaging studies with a customised humidity chamber. Rev. Sci. Instrum., 84(9), 093703, https://dx.doi.org/10.1063/1.4820913, 2013.
15. W. Kuo, L. Nimeskern, H. Martínez Ávila, S. Hofmann, J. Freedman, M. W. Grinstaff, R. Müller, K. S. Stok. Developing staining protocols for visualization of tissue-engineering scaffolds using micro computed tomography in native wet state. Proc. Gemeinsame Jahrestagung der Deutschen, österreichischen und Schweizerischen Gesellschaft für Biomedizinische Technik, Graz, Austria, September 19–21, Biomed. Tech., 58(S1):4273, 2013.
14. D. Loessner, S. C. Rizzi, K. S. Stok, T. Fuhrman, B. Hollier, V. Magdolen, D. W. Hutmacher and J. A. Clements. A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread. Biomaterials, 34(30):7389–7400, 2013.
13. L. Nimeskern, H. Martinez, J. Sundberg, P. Gatenholm, R. Müller and K. S. Stok. Mechanical evaluation of bacterial nanocellulose as an implant material for ear cartilage replacement. J. Mech. Behav. Biomed., 22C:12–21, 2013.
12. F. Rikhtegar, F. Pacheco, C.Wyss, K. S. Stok, H. Ge, R. J. Choo, A. Ferrari, R. Müller, D. Poulikakos, and V. Kurtcuoglu, Compound ex vivo and in silico method for hemodynamic analysis of stented arteries, PLoS One, 8(3):e58147,2013.
11. E. Schuh, S. Hofmann, K. S. Stok, H. Notbohm, R. Müller and N. Rotter. The influence of matrix elasticity on chondrocyte behaviour in 3D. J. Tissue Eng. Regen. M., 6(10):e31–e42, 2012.
10. E. Schuh, S. Hofmann, K. S. Stok, H. Notbohm, R. Müller and N. Rotter. Chondrocyte redifferentiation in 3D: the effect of adhesion site density and substrate elasticity. J. Biomed. Mater. Res. A, 100 (1): 38–47, 2012.
9. J. P. Moodie, K. S. Stok, R. Müller, T. L. Vincent and S. J. Shefelbine. Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity. Osteoarthr Cartilage, 19:163–170, 2011.
8. D. Loessner, K. S. Stok, M. P. Lutolf, D. W. Hutmacher, J. A. Clements, S. C. Rizzi. Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells, Biomaterials, 31(32): 8494–8506, 2010.
7. K. S. Stok, D. Noël, F. Apparailly, D. Gould, Y. Chernajovsky, C. Jorgensen and R. Müller. Quantitative imaging of cartilage and bone for functional assessment of gene therapy approaches in experimental arthritis. J. Tissue Eng. Regen. Med., 4:387–394, 2010.
6. K. S. Stok, S. Cristino, G. Lisignoli, A. Facchini and R. Müller. Mechano-functional assessment of human mesenchymal stem cells grown in three-dimensional hyaluronan-based scaffolds, J. Biomed. Mater. Res. A, 93A(1):37–45, 2010.
5. K. S. Stok, G. Pelled, Y. Zilberman, I. Kallai, D. Gazit, and R. Müller. Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints, Bone, 45:414–422, 2009.
4. K. S. Stok, and R. Müller. Morphometric characterisation of murine articular cartilage – Novel application of confocal laser scanning microscopy, Microsc. Res. Techniq., 72:650–658, 2009.
3. K. S. Stok, and A. Oloyede. Conceptual fracture parameters for articular cartilage, Clinical Biomechanics, 22(6), 2007.
2. K. S. Stok, and A. Oloyede. A qualitative analysis of crack propagation in articular cartilage at varying rates of tensile loading, Connect Tissue Res, 44 (2), 2003.
1. K. S. Stok, and A. Oloyede. Dependence of the biomechanical responses of the trabecular bone on density and strain-rate under torsional loading, The Journal of Locomotor Systems, 7 (4), 2000.