Mechanobiology and remodelling

The link between tissue composition and architecture with the resulting tissue function and integrity requires a deep understanding of the communication between biological, mechanical, and structural components of the cells (8, 20) and tissues (1–3, 11, 19, 28, 32). This is true for both engineered (6) and native tissues (29). In this work, we explore native communication pathways and develop new approaches for manipulating these in repair (12, 18, 26) and reconstruction studies (24).


32. L. Nimeskern, L. Utomo, I. Lehtoviita, G. Fessel, J. G. Snedeker, G. J.V.M van Osch, R. Müller, K. S. Stok, Tissue composition regulates distinct viscoelastic responses in auricular and articular cartilage, J. Biomech, 49(3):344-352, 2016.

29. L. Nimeskern, M. M. Pleumeekers, D. J. Pawson, W. L. M. Koevoet, I. Lehtoviita, M. B. Soyka, C. Röösli, D. Holzmann, G. J. V. M. van Osch, R. Müller and K. S. Stok. Mechanical and biochemical mapping of human auricular cartilage for reliable assessment of tissue-engineered constructs, J Biomech, 48(10): 1721–1729, 2015.

28. M. M. Pleumeekers, L. Nimeskern, W. L. M. Koevoet, M. Karperien, K. S. Stok and G. J. V. M. van Osch. Cartilage regeneration in the head and neck area: Combination of ear or nasal chondrocytes and mesenchymal stem cells improves cartilage production, Plast Reconstr Surg, 136(6): 762e-74e, 2015.

26. N. M. Kogan, E. Melamed, E. Wasserman, B. Raphael, A. Breuer, K. S. Stok, R. Sondergaard, A. V. Villarreal Escudero, S. Baraghithy, M. Attar-Namdar, S. Friedlander-Barenboim, N. Mathavan, H. Isaksson, R. Mechoulam, R. Müller, A. Bajayo, Y. Gabet and I. Bab, Cannabidiol, a major non-psychotrophic cannabis constituent enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts, JBMR, 30(10):1905-1913, 2015.

24. H. Martínez Ávila, E. Feldmann, M. M. Pleumeekers, L. Nimeskern, W. Kuo, W. C. de Jong, S. Schwarz, R. Müller, J. Hendriks, N. Rotter, G.J.V.M. van Osch, K. S. Stok and P. Gatenholm, Novel bilayer bacterial nanocellulose scaffold supports neocartilage formation in vitro and in vivo. Biomaterials, 44:122-133, 2015.

20. M.M. Pleumeekers, L. Nimeskern, W.L.M. Koevoet, N. Kops, R.M.L. Poublon, K. S. Stok, G.J.V.M. van Osch, The in vitro and in vivo capacity of culture-expanded human cells from several sources encapsulated in alginate to form cartilage. Eur. Cells. Mater, 27:265-280, 2014.

19. L. Nimeskern, G.J.V.M van Osch, R. Müller and K. S. Stok. Quantitative evaluation of mechanical properties in tissue-engineered auricular cartilage. Tissue Eng. Part B Rev., 20(1):17-27, 2014.

18. F. Rikhtegar, C. Wyss, K. S. Stok, D. Poulikakos, R. Müller and V. Kurtcuoglu. Hemodynamics in coronary arteries with overlapping stents. J. Biomech., 47(1):505-511, 2014.

12. F. Rikhtegar, F. Pacheco, C.Wyss, K. S. Stok, H. Ge, R. J. Choo, A. Ferrari, R. Müller, D. Poulikakos, and V. Kurtcuoglu, Compound ex vivo and in silico method for hemodynamic analysis of stented arteries, PLoS One, 8(3):e58147,2013.

11. E. Schuh, S. Hofmann, K. S. Stok, H. Notbohm, R. Müller and N. Rotter. The influence of matrix elasticity on chondrocyte behaviour in 3D. J. Tissue Eng. Regen. M., 6(10):e31-e42, 2012.

8. D. Loessner, K. S. Stok, M. P. Lutolf, D. W. Hutmacher, J. A. Clements, S. C. Rizzi. Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells, Biomaterials, 31(32): 8494-8506, 2010.

6. K. S. Stok, S. Cristino, G. Lisignoli, A. Facchini and R. Müller. Mechano-functional assessment of human mesenchymal stem cells grown in three-dimensional hyaluronan-based scaffolds, J. Biomed. Mater. Res. A, 93A(1):37-45, 2010.

3. K. S. Stok, and A. Oloyede. Conceptual fracture parameters for articular cartilage, Clinical Biomechanics, 22(6), 2007.

2. K. S. Stok, and A. Oloyede. A qualitative analysis of crack propagation in articular cartilage at varying rates of tensile loading, Connect Tissue Res, 44 (2), 2003.

1. K. S. Stok, and A. Oloyede. Dependence of the biomechanical responses of the trabecular bone on density and strain-rate under torsional loading, The Journal of Locomotor Systems, 7 (4), 2000.