Associate Professor Andrea O'Connor

  • Room: Level: GR Room: G01
  • Building: Chemical Engineering #2
  • Campus: Parkville

Research interests

  • 3D printing
  • Antimicrobial materials
  • Biofilms
  • Biomaterials (Biodegradable materials, scaffolds, hydrogels)
  • Medical devices (Implants)
  • Tissue engineering

Personal webpage

http://www.bme.unimelb.edu.au/tissue-engineering/

Biography

Associate Professor O'Connor is the Deputy Head of the School of Chemical and Biomedical Engineering. Her expertise is in chemical and biomedical engineering with particular focus areas including biomaterials, tissue engineering, porous materials and downstream processing for biotechnology. She leads the Tissue Engineering Research Group in the Department of Biomedical Engineering.

Her research and teaching are focused in cross disciplinary applications of engineering involving biological systems, including a strong interest in 3D soft tissue engineering. She has active collaborations with several medical research institutes and medical device companies in Australia and has worked in the chemical industry in Australia and overseas.

Current Research Activities include:
Nano and Biomolecular Engineering - Tissue engineering Nanostructured materials
Bioprocess Engineering - Separations technology 3D printing

Recent publications

  1. Onofrillo C, Duchi S, O'Connell CD, Blanchard R, O'Connor A, Scott M, Wallace GG, Choong P, Di Bella C. Biofabrication of human articular cartilage: a path towards the development of a clinical treatment. BIOFABRICATION. Institute of Physics Publishing. 2018, Vol. 10, Issue 4. DOI: 10.1088/1758-5090/aad8d9
  2. Biswas D, O'Brien-Simpson N, Reynolds E, O'Connor A, Tran P. Comparative study of novel in situ decorated porous chitosan-selenium scaffolds and porous chitosan-silver scaffolds towards antimicrobial wound dressing application. JOURNAL OF COLLOID AND INTERFACE SCIENCE. Academic Press. 2018, Vol. 515. DOI: 10.1016/j.jcis.2018.01.007
  3. Karimi F, O'Connor A, Qiao G, Heath D. Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin-Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration. ADVANCED HEALTHCARE MATERIALS. Wiley - V C H Verlag GmbH & Co. KGaA. 2018, Vol. 7, Issue 12. DOI: 10.1002/adhm.201701324
  4. Herson MR, Hamilton K, White J, Alexander D, Poniatowski S, O'Connor A, Werkmeister JA. Interaction of preservation methods and radiation sterilization in human skin processing, with particular insight on the impact of the final water content and collagen disruption. Part I: process validation, water activity and collagen changes in tissues cryopreserved or processed using 50, 85 or 98% glycerol solutions. CELL AND TISSUE BANKING. Springer Verlag. 2018, Vol. 19, Issue 2. DOI: 10.1007/s10561-018-9694-1
  5. Gu D, Tan S, O'Connor A, Qiao G. On-Demand Cascade Release of Hydrophobic Chemotherapeutics from a Multicomponent Hydrogel System. ACS BIOMATERIALS SCIENCE & ENGINEERING. American Chemical Society. 2018, Vol. 4, Issue 5. DOI: 10.1021/acsbiomaterials.8b00166
  6. O'Connor A, Marre D, Yap KK, Heath D, Morrison W. Tissue Engineering. Plastic Surgery, Volume 1: Principles. 2018. Editors: Gurtner GC.
  7. Kusuma G, Yang M, Brennecke S, O'Connor A, Kalionis B, Heath D. Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up. ACS BIOMATERIALS SCIENCE & ENGINEERING. American Chemical Society. 2018, Vol. 4, Issue 5. DOI: 10.1021/acsbiomaterials.7b00747
  8. Biswas D, Tran P, Tallon Galdeano C, O'Connor A. Combining mechanical foaming and thermally induced phase separation to generate chitosan scaffolds for soft tissue engineering. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. VSP. 2017, Vol. 28, Issue 2. DOI: 10.1080/09205063.2016.1262164
  9. Kusuma G, Brennecke S, O'Connor A, Kalionis B, Heath D. Decellularized extracellular matrices produced from immortal cell lines derived from different parts of the placenta support primary mesenchymal stem cell expansion. PLOS ONE. Public Library of Science. 2017, Vol. 12, Issue 2. DOI: 10.1371/journal.pone.0171488
  10. Gu D, Tan S, Xu C, O'Connor A, Qiao G. Engineering tough, highly compressible, biodegradable hydrogels by tuning the network architecture. CHEMICAL COMMUNICATIONS. Royal Society of Chemistry. 2017, Vol. 53, Issue 50. DOI: 10.1039/c7cc02811c
  11. Gu D, O'Connor A, Qiao G, Ladewig K. Hydrogels with smart systems for delivery of hydrophobic drugs. EXPERT OPINION ON DRUG DELIVERY. Informa Healthcare. 2017, Vol. 14, Issue 7. DOI: 10.1080/17425247.2017.1245290
  12. Braunger J, Bjornmalm A, Isles N, Cui J, Henderson T, O'Connor A, Caruso F. Interactions between circulating nanoengineered polymer particles and extracellular matrix components in vitro. BIOMATERIALS SCIENCE. R S C Publications. 2017, Vol. 5, Issue 2. DOI: 10.1039/c6bm00726k
  13. Karimi F, McKenzie T, O'Connor A, Qiao G, Heath D. Nano-scale clustering of integrin-binding ligands regulates endothelial cell adhesion, migration, and endothelialization rate: novel materials for small diameter vascular graft applications. JOURNAL OF MATERIALS CHEMISTRY B. RSC Press. 2017, Vol. 5, Issue 30. DOI: 10.1039/c7tb01298e
  14. Shakouri-Motlagh A, O'Connor A, Brennecke S, Kalionis B, Heath D. Native and solubilized decellularized extracellular matrix: A critical assessment of their potential for improving the expansion of mesenchymal stem cells. ACTA BIOMATERIALIA. Elsevier BV. 2017, Vol. 55. DOI: 10.1016/j.actbio.2017.04.014
  15. O'Connor A, Vinu A. Proceedings of the 9th International Mesostructured Materials Symposium. MICROPOROUS AND MESOPOROUS MATERIALS. Elsevier Science. 2017, Vol. 238. DOI: 10.1016/j.micromeso.2016.09.042

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile