Dr Daniel Heath

  • Room: Level: 03 Room: 310
  • Building: Chemical Engineering #1
  • Campus: Parkville

Research interests

  • Blood-material interactions
  • Decellularization
  • Endothelialization of biomaterials
  • Extracellular matrix materials
  • Stem cell manufacturing

Personal webpage



Daniel Heath is a Lecturer with University of Melbourne's School of Chemical and Biomedical Engineering. His research focuses on developing next generation biomaterials. He has specific interest in blood-material interactions, as poor interactions between blood and biomaterials leads to the failure of many medical devices including vascular grafts and stents. His lab hopes to address these challenges by developing new biomaterials with improved blood-material interactions. In many ways, cells are the best producers of biomaterials. Therefore, the Heath Lab also looks at extracellular matrix materials and their applications as biomaterials. Core to this technology is the decellularization of tissue or cell cultures in order to produce extracellular matrix materials that can be used for a variety of applications.

Recent publications

  1. Shakouri-Motlagh A, O'Connor A, Kalionis B, Heath D. Improved ex vivo expansion of mesenchymal stem cells on solubilized acellular fetal membranes. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. Wiley-Liss. 2019, Vol. 107, Issue 1. DOI: 10.1002/jbm.a.36557
  2. Karimi F, Thombare V, Hutton C, O'Connor A, Qiao G, Heath D. Beyond RGD; nanoclusters of syndecan- and integrin-binding ligands synergistically enhance cell/material interactions. BIOMATERIALS. Elsevier Science. 2018, Vol. 187. DOI: 10.1016/j.biomaterials.2018.10.002
  3. Karimi F, O'Connor A, Qiao G, Heath D. Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin-Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration. ADVANCED HEALTHCARE MATERIALS. Wiley - V C H Verlag GmbH & Co. KGaA. 2018, Vol. 7, Issue 12. DOI: 10.1002/adhm.201701324
  4. Kusuma G, Yang M, Brennecke S, O'Connor A, Kalionis B, Heath D. Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up. ACS BIOMATERIALS SCIENCE & ENGINEERING. American Chemical Society. 2018, Vol. 4, Issue 5. DOI: 10.1021/acsbiomaterials.7b00747
  5. Kusuma G, Brennecke S, O'Connor A, Kalionis B, Heath D. Decellularized extracellular matrices produced from immortal cell lines derived from different parts of the placenta support primary mesenchymal stem cell expansion. PLOS ONE. Public Library of Science. 2017, Vol. 12, Issue 2. DOI: 10.1371/journal.pone.0171488
  6. Karimi F, Collins J, Heath D, Connal L. Dynamic Covalent Hydrogels for Triggered Cell Capture and Release. BIOCONJUGATE CHEMISTRY. American Chemical Society. 2017, Vol. 28, Issue 9. DOI: 10.1021/acs.bioconjchem.7b00360
  7. Karimi F, McKenzie T, O'Connor A, Qiao G, Heath D. Nano-scale clustering of integrin-binding ligands regulates endothelial cell adhesion, migration, and endothelialization rate: novel materials for small diameter vascular graft applications. JOURNAL OF MATERIALS CHEMISTRY B. RSC Press. 2017, Vol. 5, Issue 30. DOI: 10.1039/c7tb01298e
  8. Shakouri-Motlagh A, O'Connor A, Brennecke S, Kalionis B, Heath D. Native and solubilized decellularized extracellular matrix: A critical assessment of their potential for improving the expansion of mesenchymal stem cells. ACTA BIOMATERIALIA. Elsevier BV. 2017, Vol. 55. DOI: 10.1016/j.actbio.2017.04.014
  9. Heath D. Promoting Endothelialization of Polymeric Cardiovascular Biomaterials. MACROMOLECULAR CHEMISTRY AND PHYSICS. Wiley - V C H Verlag GmbH & Co. KGaA. 2017, Vol. 218, Issue 8. DOI: 10.1002/macp.201600574
  10. Shakouri-Motlagh A, Khanabdali R, Heath D, Kalionis B. The application of decellularized human term fetal membranes in tissue engineering and regenerative medicine (TERM). PLACENTA. WB Saunders Co. 2017, Vol. 59. DOI: 10.1016/j.placenta.2017.07.002
  11. Heath D, Cooper SL. The development of polymeric biomaterials inspired by the extracellular matrix. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. VSP. 2017, Vol. 28, Issue 10-12. DOI: 10.1080/09205063.2017.1297285
  12. O'Connor A, Marre D, Yap KK, Heath D, Morrison W. Tissue Engineering. Plastic Surgery, Volume 1: Principles. 2017. Editors: Gurtner GC.
  13. Xiao Z, Bonnard T, Shakouri-Motlagh A, Wylie R, Collins J, White J, Heath D, Hagemeyer CE, Connal L. Triggered and Tunable Hydrogen Sulfide Release from Photogenerated Thiobenzaldehydes. CHEMISTRY-A EUROPEAN JOURNAL. Wiley-VCH. 2017, Vol. 23, Issue 47. DOI: 10.1002/chem.201701206
  14. Heath D, Kang GCW, Cao Y, Poon YF, Chan V, Chan-Park MB. Biomaterials patterned with discontinuous microwalls for vascular smooth muscle cell culture: biodegradable small diameter vascular grafts and stable cell culture substrates. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. VSP. 2016, Vol. 27, Issue 15. DOI: 10.1080/09205063.2016.1213217
  15. Shirbin S, Karimi F, Chan NJ-A, Heath D, Qiao G. Macroporous Hydrogels Composed Entirely of Synthetic Polypeptides: Biocompatible and Enzyme Biodegradable 3D Cellular Scaffolds. BIOMACROMOLECULES. American Chemical Society. 2016, Vol. 17, Issue 9. DOI: 10.1021/acs.biomac.6b00817

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile