Dr Daniel Heath

  • Room: Level: 03 Room: 310
  • Building: Chemical Engineering #1
  • Campus: Parkville

Research interests

  • Blood-material interactions
  • Decellularization
  • Endothelialization of biomaterials
  • Extracellular matrix materials
  • Stem cell manufacturing

Personal webpage



Daniel Heath is a Senior Lecturer in the University of Melbourne's Department of Biomedical Engineering. His research focuses on developing next generation biomaterials. He has specific interest in blood-material interactions, as poor interactions between blood and biomaterials leads to the failure of many medical devices including vascular grafts and stents. His lab hopes to address these challenges by developing new biomaterials with improved blood-material interactions. In many ways, cells are the best producers of biomaterials. Therefore, the Heath Lab also looks at extracellular matrix materials and their applications as biomaterials. Core to this technology is the decellularization of tissue or cell cultures in order to produce extracellular matrix materials that can be used for a variety of applications.

Recent publications

  1. Heath D. A Review of Decellularized Extracellular Matrix Biomaterials for Regenerative Engineering Applications. REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE. Dr Dietrich Steinkopff Verlag. 2019, Vol. 5, Issue 2. DOI: 10.1007/s40883-018-0080-0
  2. Huang T, Holden J, Heath D, O'Brien-Simpson N, O'Connor A. Engineering highly effective antimicrobial selenium nanoparticles through control of particle size. Nanoscale. Royal Society of Chemistry. 2019, Vol. 11, Issue 31. DOI: 10.1039/c9nr04424h
  3. Shakouri-Motlagh A, O'Connor A, Kalionis B, Heath D. Improved ex vivo expansion of mesenchymal stem cells on solubilized acellular fetal membranes. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. Wiley-Liss. 2019, Vol. 107, Issue 1. DOI: 10.1002/jbm.a.36557
  4. Karimi F, Thombare V, Hutton C, O'Connor A, Qiao G, Heath D. Beyond RGD; nanoclusters of syndecan- and integrin-binding ligands synergistically enhance cell/material interactions. BIOMATERIALS. Elsevier Science. 2018, Vol. 187. DOI: 10.1016/j.biomaterials.2018.10.002
  5. Karimi F, O'Connor A, Qiao G, Heath D. Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin-Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration. ADVANCED HEALTHCARE MATERIALS. Wiley - V C H Verlag GmbH & Co. KGaA. 2018, Vol. 7, Issue 12. DOI: 10.1002/adhm.201701324
  6. Kusuma G, Yang M, Brennecke S, O'Connor A, Kalionis B, Heath D. Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up. ACS BIOMATERIALS SCIENCE & ENGINEERING. American Chemical Society. 2018, Vol. 4, Issue 5. DOI: 10.1021/acsbiomaterials.7b00747
  7. Kusuma G, Brennecke S, O'Connor A, Kalionis B, Heath D. Decellularized extracellular matrices produced from immortal cell lines derived from different parts of the placenta support primary mesenchymal stem cell expansion. PLOS ONE. Public Library of Science. 2017, Vol. 12, Issue 2. DOI: 10.1371/journal.pone.0171488
  8. Karimi F, Collins J, Heath D, Connal L. Dynamic Covalent Hydrogels for Triggered Cell Capture and Release. BIOCONJUGATE CHEMISTRY. American Chemical Society. 2017, Vol. 28, Issue 9. DOI: 10.1021/acs.bioconjchem.7b00360
  9. Karimi F, McKenzie T, O'Connor A, Qiao G, Heath D. Nano-scale clustering of integrin-binding ligands regulates endothelial cell adhesion, migration, and endothelialization rate: novel materials for small diameter vascular graft applications. JOURNAL OF MATERIALS CHEMISTRY B. RSC Press. 2017, Vol. 5, Issue 30. DOI: 10.1039/c7tb01298e
  10. Shakouri-Motlagh A, O'Connor A, Brennecke S, Kalionis B, Heath D. Native and solubilized decellularized extracellular matrix: A critical assessment of their potential for improving the expansion of mesenchymal stem cells. ACTA BIOMATERIALIA. Elsevier BV. 2017, Vol. 55. DOI: 10.1016/j.actbio.2017.04.014
  11. Heath D. Promoting Endothelialization of Polymeric Cardiovascular Biomaterials. MACROMOLECULAR CHEMISTRY AND PHYSICS. Wiley - V C H Verlag GmbH & Co. KGaA. 2017, Vol. 218, Issue 8. DOI: 10.1002/macp.201600574
  12. Shakouri-Motlagh A, Khanabdali R, Heath D, Kalionis B. The application of decellularized human term fetal membranes in tissue engineering and regenerative medicine (TERM). PLACENTA. WB Saunders Co. 2017, Vol. 59. DOI: 10.1016/j.placenta.2017.07.002
  13. Heath D, Cooper SL. The development of polymeric biomaterials inspired by the extracellular matrix. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. VSP. 2017, Vol. 28, Issue 10-12. DOI: 10.1080/09205063.2017.1297285
  14. O'Connor A, Marre D, Yap KK, Heath D, Morrison W. Tissue Engineering. Plastic Surgery, Volume 1: Principles. 2017. Editors: Gurtner GC.
  15. Xiao Z, Bonnard T, Shakouri-Motlagh A, Wylie R, Collins J, White J, Heath D, Hagemeyer CE, Connal L. Triggered and Tunable Hydrogen Sulfide Release from Photogenerated Thiobenzaldehydes. CHEMISTRY-A EUROPEAN JOURNAL. Wiley-VCH. 2017, Vol. 23, Issue 47. DOI: 10.1002/chem.201701206

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile