Professor Edmund Crampin

Research interests

  • Biomedical Engineering
  • Mathematical Biology
  • Systems Biology

Personal webpage


Professor Edmund Crampin is Rowden White Chair of Systems Biology at the University of Melbourne. Edmund directs the Systems Biology Lab at the School of Mathematics and Statistics and the Department of Biomedical Engineering, and is Adjunct Professor in the Faculty of Medicine, Dentistry and Health Sciences (School of Medicine). The Systems Biology Lab is a highly collaborative group using mathematical and computer modelling to investigate cellular regulatory processes and biophysical mechanisms underlying complex human diseases, major challenges in biotechnology, and synthetic biology. The group is currently pioneering energy-based approaches to describing and analysing cellular processes. Current projects include modelling heart cells to understand the development of heart disease; interactions between cells and nanoparticles; and studying the network of genetic interactions underlying breast and skin cancer. Edmund graduated with a BSc (Hons) in Physics from Imperial College London, and a DPhil in Applied Mathematics at the University of Oxford where his thesis topic was on biological pattern formation, advised by Professor Philip Maini FRS. Edmund was elected to a Junior Research Fellowship at Brasenose College Oxford and awarded a Wellcome Trust Research Fellowship to study mathematical models of heart disease, with Professor Denis Noble FRS. In 2003 Edmund moved from Oxford to New Zealand to establish the Systems Biology group at the Auckland Bioengineering Institute, in collaboration with Institute director Professor Peter Hunter FRS. Edmund moved to the University of Melbourne in 2013 to take up the Chair of Systems Biology.

Recent publications

  1. Pan M, Gawthrop P, Tran K, Cursons J, Crampin E. A thermodynamic framework for modelling membrane transporters. JOURNAL OF THEORETICAL BIOLOGY. Academic Press. 2019, Vol. 481. DOI: 10.1016/j.jtbi.2018.09.034
  2. Johnston S, Crampin E. Corrected pair correlation functions for environments with obstacles. Physical Review E: covering statistical, nonlinear, biological, and soft matter physics. American Physical Society. 2019, Vol. 99, Issue 3. DOI: 10.1103/PhysRevE.99.032124
  3. Ladd D, Tilunaite A, Soeller C, Roderick L, Crampin E, Rajagopal V. Detecting RyR clusters with CaCLEAN: influence of spatial distribution and structural heterogeneity. . 2019. DOI: 10.1101/549683
  4. Gawthrop P, Crampin E. Energetic Modelling of Mitochondrial Redox Reactions. 63rd Annual Meeting of the Biophysical-Society. Biophysical Society. 2019, Vol. 116, Issue 3. DOI: 10.1016/j.bpj.2018.11.2256
  5. Faria M, Noi K, Johnston S, Ju Y, Bjornmalm M, Caruso F, Crampin E. Kinetic Modeling of Nanoparticle-Cell Association. 63rd Annual Meeting of the Biophysical-Society. Biophysical Society. 2019, Vol. 116, Issue 3. DOI: 10.1016/j.bpj.2018.11.2399
  6. Weiss A, Kelly H, Faria M, Besford Q, Wheatley A, Ang C, Crampin E, Caruso F, Kent S. Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles. ACS Nano. American Chemical Society. 2019, Vol. 13, Issue 5. DOI: 10.1021/acsnano.9b00552
  7. Siekmann I, Bjelosevic S, Landman K, Monagle P, Ignjatovic V, Crampin E. Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration. SCIENTIFIC REPORTS. Nature Publishing Group. 2019, Vol. 9, Issue 1. DOI: 10.1038/s41598-019-40435-7
  8. Johnston S, Faria M, Crampin E. Quantifying the Influence of Nanoparticle Polydispersity on Cellular Delivered Dose. 63rd Annual Meeting of the Biophysical-Society. Biophysical Society. 2019, Vol. 116, Issue 3. DOI: 10.1016/j.bpj.2018.11.221
  9. Faria M, Noi K, Dai Q, Bjornmalm A, Johnston S, Kempe K, Caruso F, Crampin E. Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.. Journal of Controlled Release. Elsevier Science. 2019, Vol. 307. DOI: 10.1016/j.jconrel.2019.06.027
  10. Johnston S, Faria M, Crampin E. An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose. JOURNAL OF THE ROYAL SOCIETY INTERFACE. The Royal Society Publishing. 2018, Vol. 15, Issue 144. DOI: 10.1098/rsif.2018.0364
  11. Gawthrop P, Crampin E. Biomolecular system energetics. Simulation Series. 2018, Vol. 50, Issue 12.
  12. Pan M, Gawthrop P, Tran K, Cursons J, Crampin E. Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. The Royal Society of London. 2018, Vol. 474, Issue 2214. DOI: 10.1098/rspa.2018.0106
  13. Gawthrop P, Crampin E. Bond Graph Representation of Chemical Reaction Networks. IEEE TRANSACTIONS ON NANOBIOSCIENCE. IEEE - Institute of Electrical and Electronic Engineers. 2018, Vol. 17, Issue 4. DOI: 10.1109/TNB.2018.2876391
  14. Cursons J, Pillman KA, Scheer KG, Gregory PA, Foroutan M, Hediyeh-Zadeh S, Toubia J, Crampin E, Goodall GJ, Bracken CP, Davis M. Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT. CELL SYSTEMS. Cell Press. 2018, Vol. 7, Issue 1. DOI: 10.1016/j.cels.2018.05.019
  15. Rajagopal V, Bass G, Ghosh S, Hunt H, Walkers C, Hanssen E, Crampin E, Soeller C. Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. Journal of Visualized Experiments. 2018, Vol. 2018, Issue 134. DOI: 10.3791/56817

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile