Dr Kathryn Stok

  • Room: Level: Room: G28
  • Building: 203 Bouverie St
  • Campus: Parkville

Research interests

  • Mechanobiology: quantitative microstructural imaging and mechanics of cartilage and joints using experimental and computational approaches. (mechanobiology; quantitative; micro-computed tomography; materials testing; mechanical evaluation)

Biography

Dr Kathryn Stok (FIEAust) is a Senior Lecturer of Mechanobiology in the Department of Biomedical Engineering at the University of Melbourne, and an innovative biomedical engineer in quantitative microstructural imaging (micro-computed tomography) and biomechanics of cartilage and joint structures. She uses a variety of experimental and computational approaches. Her research work merges solid engineering approaches with biomedical advancement.

She was awarded a PhD from ETH Zurich, Switzerland in 2008. This work involved devising novel imaging and mechanical platforms for quantitative measurement of articular cartilage. In 2008, Dr Stok founded the Integrative Cartilage Research (ICR) Group at ETH Zurich, establishing industrial and clinical collaboration, winning four consortium grants, and multiple subcontracts in quantitative mechanobiology around the themes of microstructural imaging of biological tissues and organs, and characterisation (mechanical and structural) of regenerative medicine materials and tissue engineered constructs.

In September 2016, Dr Stok took up a position at the University of Melbourne to continue this work. She aims to improve mechanobiological measurement and control methods using novel imaging, mechanics and computational modelling. This involves the development of novel, in vivo, imaging-based measurement technologies for hard and soft biological tissues in 3D at different length scales. It will further enable investigation of joint health, with commercial potential in imaging, mechanobiology and biofabrication, and translation into Medtech patents and spinoffs. She Heads the Integrative Cartilage Research Group, and is a co-founder of the Melbourne School of Engineering Mechanobiology Lab in the Parkville Biomedical Precinct: www.integrativecartilageresearchgroup.com

Recent publications

  1. Mattei C, Lim R, Drury H, Nasr B, Li Z, Tadros MA, D'Abaco GM, Stok K, Nayagam B, Dottori M. Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2019, Vol. 7. DOI: 10.3389/fcell.2019.00025
  2. Lehmann J, NÜrnberger S, Narcisi R, Stok K, Van Der Eerden BCJ, Koevoet WJLM, Kops N, Ten Berge D, Van Osch GJ. Recellularization of auricular cartilage via elastase-generated channels.. Biofabrication. 2019, Vol. 11, Issue 3. DOI: 10.1088/1758-5090/ab1436
  3. Flurey CA, Tugwell PS, Black RJ, Halls S, Page MJ, Robson JC, Sahbudin I, Siddle HJ, Sinnathurai P, Stok K, Richards B. The OMERACT Emerging Leaders Program: The Good, the Bad, and the Future. Journal of Rheumatology. Journal of Rheumatology Publication Co. 2019, Vol. 46, Issue 8. DOI: 10.3899/jrheum.181126
  4. Manske SL, Brunet SC, Finzel S, Stok K, Conaghan PG, Boyd SK, Barnabe C. The SPECTRA Collaboration OMERACT Working Group: Criterion Validity of Joint Space Outcomes with High Resolution Peripheral Quantitative Computed Tomography.. J Rheumatol. Journal of Rheumatology Publication Co. 2019. DOI: 10.3899/jrheum.180870
  5. Peters M, De Jong J, Scharmga A, Van Tubergen A, Geusens P, Loeffen D, Weijers R, Boyd SK, Barnabe C, Stok K, Van Rietbergen B, Van Den Bergh J. An automated algorithm for the detection of cortical interruptions and its underlying loss of trabecular bone; a reproducibility study. BMC MEDICAL IMAGING. Biomed Central. 2018, Vol. 18, Issue 1. DOI: 10.1186/s12880-018-0255-7
  6. Pleumeekers MM, Nimeskern L, Koevoet JLM, Karperien M, Stok K, Van Osch GJVM. Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture.. PLoS One. Public Library of Science. 2018, Vol. 13, Issue 2. DOI: 10.1371/journal.pone.0190744
  7. Stok K, Finzel S, Burghardt AJ, Conaghan PG, Barnabe C. The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions. International Consensus Conference on Outcome Measures in Rheumatology (OMERACT). Journal of Rheumatology Publication Co. 2017, Vol. 44, Issue 12. DOI: 10.3899/jrheum.161197
  8. Lakin BA, Patel H, Holland C, Freedman JD, Shelofsky JS, Snyder BD, Stok K, Grinstaff MW. Contrast-enhanced CT using a cationic contrast agent enables non-destructive assessment of the biochemical and biomechanical properties of mouse tibial plateau cartilage. JOURNAL OF ORTHOPAEDIC RESEARCH. Elsevier Science. 2016, Vol. 34, Issue 7. DOI: 10.1002/jor.23141
  9. Barnabe C, Toepfer D, Marotte H, Hauge E-M, Scharmga A, Kocijan R, Kraus S, Boutroy S, Schett G, Keller KK, De Jong J, Stok K, Finzel S, Spectra Collaboration. Definition for Rheumatoid Arthritis Erosions Imaged with High Resolution Peripheral Quantitative Computed Tomography and Interreader Reliability for Detection and Measurement.. J Rheumatol. Journal of Rheumatology Publication Co. 2016, Vol. 43, Issue 10. DOI: 10.3899/jrheum.160648
  10. Tom S, Frayne M, Manske SL, Burghardt AJ, Stok K, Boyd SK, Barnabe C. Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography.. J Rheumatol. Journal of Rheumatology Publication Co. 2016, Vol. 43, Issue 10. DOI: 10.3899/jrheum.160649
  11. Walser J, Stok K, Caversaccio MD, Ferguson SJ. Direct electrospinning of 3D auricle-shaped scaffolds for tissue engineering applications. BIOFABRICATION. Institute of Physics Publishing. 2016, Vol. 8, Issue 2. DOI: 10.1088/1758-5090/8/2/025007
  12. Nagaraj S, Finzel S, Stok K, Barnabe C, Spectra Collaboration. High-resolution Peripheral Quantitative Computed Tomography Imaging in the Assessment of Periarticular Bone of Metacarpophalangeal and Wrist Joints.. J Rheumatol. Journal of Rheumatology Publication Co. 2016, Vol. 43, Issue 10. DOI: 10.3899/jrheum.160647
  13. Stok K, Besler BA, Steiner TH, Escudero AVV, Zulliger MA, Wilke M, Atal K, Quintin A, Koller B, Mueller R, Nesic D. Three-Dimensional Quantitative Morphometric Analysis (QMA) for In Situ Joint and Tissue Assessment of Osteoarthritis in a Preclinical Rabbit Disease Model. PLOS ONE. Public Library of Science. 2016, Vol. 11, Issue 1. DOI: 10.1371/journal.pone.0147564
  14. Nimeskern L, Utomo L, Lehtoviita I, Fessel G, Snedeker JG, Van Osch GJVM, Mueller R, Stok K. Tissue composition regulates distinct viscoelastic responses in auricular and articular cartilage. JOURNAL OF BIOMECHANICS. Pergamon. 2016, Vol. 49, Issue 3. DOI: 10.1016/j.jbiomech.2015.12.032
  15. Kogan NM, Melamed E, Wasserman E, Raphael B, Breuer A, Stok K, Sondergaard R, Escudero AW, Baraghithy S, Attar-Namdar M, Friedlander-Barenboim S, Mathavan N, Isaksson H, Mechoulam R, Mueller R, Bajayo A, Gabet Y, Bab I. Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts. JOURNAL OF BONE AND MINERAL RESEARCH. American Society for Bone and Mineral Research. 2015, Vol. 30, Issue 10. DOI: 10.1002/jbmr.2513

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile