Professor Mark Cook

  • Room: Level: 04 Room: 404
  • Building: Clinical Sciences Block
  • Campus: St Vincents Hospital

Research interests

  • Neurology (Epilepsy)


Director of The Graeme Clark Institute, The Sir John Eccles Chair of Medicine and Director of Clinical Neurosciences at St. Vincent’s Hospital, Professor Cook specialises in the treatment of epilepsy. He is recognised internationally for his expertise in epilepsy management, particularly imaging and surgical planning. After completing specialist training in Melbourne, he undertook an MD thesis while working as Brain Research Fellow at Queen Square, London. He returned to St. Vincent’s Hospital, Melbourne to continue his interest in management of complex epilepsy. He has worked closely with engineers for most of his career, developing novel therapies for epilepsy. His interests have included experimental models of epilepsy and seizure prediction, and he has led the commercialisation of an implantable seizure detection device about to start clinical trials.

Recent publications

  1. Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez M, Johannsen VA, Cook M, Crowston J, Hill A, Duce J, Bush A, Trounce I. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. MOLECULAR NEUROBIOLOGY. Humana Press. 2019, Vol. 56, Issue 8. DOI: 10.1007/s12035-018-1460-7
  2. Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez M, Johanssen VA, Cook M, Crowston J, Hill A, Duce J, Bush A, Trounce I. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019). MOLECULAR NEUROBIOLOGY. Humana Press. 2019, Vol. 56, Issue 10. DOI: 10.1007/s12035-019-01726-2
  3. Allebone J, Kanaan R, Maller J, O'Brien T, Mullen S, Cook M, Adams S, Vogrin S, Vaughan D, Connelly A, Kwan P, Berkovic S, D'Souza W, Jackson G, Velakoulis D, Wilson S. Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. BMJ Publishing Group. 2019, Vol. 90, Issue 6. DOI: 10.1136/jnnp-2018-319396
  4. Baldassano S, Zhao X, Brinkmann B, Kremen V, Bernabei J, Cook M, Denison T, Worrell G, Litt B. Cloud computing for seizure detection in implanted neural devices. JOURNAL OF NEURAL ENGINEERING. Institute of Physics Publishing. 2019, Vol. 16, Issue 2. DOI: 10.1088/1741-2552/aaf92e
  5. Clarke S, Karoly P, Nurse E, Seneviratne U, Taylor J, Knight-Sadler R, Kerr R, Moore B, Hennessy P, Mendis D, Lim C, Miles J, Cook M, Freestone D, D'Souza W. Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy.. Epilepsy Behav. 2019. DOI: 10.1016/j.yebeh.2019.106556
  6. Dell K, Cook M, Maturana M. Deep Brain Stimulation for Epilepsy: Biomarkers for Optimization. CURRENT TREATMENT OPTIONS IN NEUROLOGY. Current Science. 2019, Vol. 21, Issue 10. DOI: 10.1007/s11940-019-0590-1
  7. Cook B, Cook M. Does my posterior look big in this?—Bayesian solutions to seizure counting problems. Epilepsia Open. 2019, Vol. 4, Issue 2. DOI: 10.1002/epi4.12328
  8. Gilbert F, Cook M, O'Brien T, Illes J. Embodiment and Estrangement: Results from a First-in-Human "Intelligent BCI" Trial. SCIENCE AND ENGINEERING ETHICS. Springer. 2019, Vol. 25, Issue 1. DOI: 10.1007/s11948-017-0001-5
  9. Woldman W, Cook M, Terry JR. Evolving dynamic networks: An underlying mechanism of drug resistance in epilepsy?. EPILEPSY & BEHAVIOR. Academic Press - Elsevier Science. 2019, Vol. 94. DOI: 10.1016/j.yebeh.2019.03.003
  10. Plummer C, Vogrin S, Woods WP, Murphy M, Cook M, Liley D. Interictal and ictal source localization for epilepsy surgery using high-density EEG with MEG: a prospective long-term study. BRAIN. Oxford University Press. 2019, Vol. 142, Issue 4. DOI: 10.1093/brain/awz015
  11. Seneviratne U, Karoly P, Freestone D, Cook M, Boston R. Methods for the Detection of Seizure Bursts in Epilepsy. FRONTIERS IN NEUROLOGY. Frontiers Research Foundation. 2019, Vol. 10. DOI: 10.3389/fneur.2019.00156
  12. Kamel J, Loh M, Cook M, MacIsaac R, Roberts L. Reducing glucose variability with continuous subcutaneous insulin infusion is associated with reversal of axonal dysfunction in type 1 diabetes mellitus. MUSCLE & NERVE. John Wiley & Sons. 2019. DOI: 10.1002/mus.26738
  13. Tan M, Boston R, Cook M, D'Souza W. Risk factors for injury in a community-treated cohort of patients with epilepsy in Australia. 68th Annual Meeting of the American-Academy-of-Neurology (AAN). Blackwell Science. 2019, Vol. 60, Issue 3. DOI: 10.1111/epi.14659
  14. George A, Kuzniecky R, Rusinek H, Pardoe HR, French J, Lowenstein D, Cristofaro S, McKenna K, Mays V, Shack D, Barnard S, Burke C, Hegde M, Glauser T, O'Brien T, Pollard J, Ting T, Meador K, Darby D, Morrison C, Penovich P, Schembri A, Kanner A, Altilab HH, Barry J, Hesdorffer D, Hope O, Nadkarni S, Sperling M, Winawer M, Dlugos D, Beal J, Boro A, Herman S, Singh R, Halford J, Thio LL, Pardoe H, Cascino G, Glynn S, Jackson G, Knowlton R, Gidal B, Abou-Khalil B, Alldredge B, Faught E, Ficker D, Klein P, Mintzer S, Detyniecki K, Haut S, Hixson J, Holmes M, Kalviainen R, Widdess-Walsh P, Krishnamurthy K, Park K, Gelfand M, Kang J, Krauss G, Cole A, Cascino G, Halford J, Atkinson P, Trinka E, Kirschner M, Schmid E, Somerville E, Zentner C, Laue-Gizzi H, Rodriguez A, Devinsky O, Nadkarni M, Cook M, Berkovic S, Bebin M, Szaflarsk J, Szabo C, Burneo J, Abou-Khalil BW, Weisenberg J, Altilab H. Standardized Brain MRI Acquisition Protocols Improve Statistical Power in Multicenter Quantitative Morphometry Studies. JOURNAL OF NEUROIMAGING. Sage Science Press. 2019. DOI: 10.1111/jon.12673
  15. Edward K-L, Cook M, Stephenson J, Giandinoto J-A. The impact of brief lifestyle self-management education for the control of seizures.. Br J Nurs. 2019, Vol. 28, Issue 6. DOI: 10.12968/bjon.2019.28.6.348

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile