Dr Niloufar Ansari

  • Room: Level: Room: G23
  • Building: 203 Bouverie St
  • Campus: Parkville

Research interests

  • Biomedical engineering
  • Bone Biology and diseases
  • Cell Signaling
  • Pharmacology and Pharmaceutical Sciences
  • Skeletal system and disorders

Biography

Dr Ansari is a Postdoctoral Researcher in the Department of Biomedical Engineering at the University of Melbourne. She trained in both pharmacology (PharmD) and in bone cell biology (PhD). She completed her PhD in Medicine, Dentistry & Health Sciences at the University of Melbourne (October 2018). During her PhD, she worked at St Vincent’s Institute of Medical Research (SVI), where she studied the physiological role of osteocytic parathyroid hormone-related protein. She is an expert in studying cell function in vitro and in vivo, using genetically modified models. In March 2019, she joined the Integrative Cartilage Research Group of Dr Kathryn Stok at the University of Melbourne, working on in vivo imaging of cartilage and the whole joint.

Recent publications

  1. Ansari N, Ho PW, Crimeen-Irwin B, Poulton IJ, Brunt AR, Forwood MR, Pajevic PD, Gooi J, Martin T, Sims N. Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein. JOURNAL OF BONE AND MINERAL RESEARCH. American Society for Bone and Mineral Research. 2018, Vol. 33, Issue 1. DOI: 10.1002/jbmr.3291
  2. Ansari N, Hadi-Alijanvand H, Sabbaghian M, Kiaei M, Khodagholi F. Interaction of 2-APB, dantrolene, and TDMT with IP3R and RyR modulates ER stress-induced programmed cell death I and II in neuron-like PC12 cells: an experimental and computational investigation. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. Adenine Press. 2014, Vol. 32, Issue 8. DOI: 10.1080/07391102.2013.812520
  3. Sarvestani NN, Khodagholi F, Ansari N, Farimani MM. Involvement of p-CREB and phase II detoxifying enzyme system in neuroprotection mediated by the flavonoid calycopterin isolated from Dracocephalum kotschyi. PHYTOMEDICINE. Urban und Fischer Verlag. 2013, Vol. 20, Issue 10. DOI: 10.1016/j.phymed.2013.03.013
  4. Ansari N, Khodagholi F. Molecular mechanism aspect of ER stress in Alzheimer's disease: current approaches and future strategies.. Curr Drug Targets. 2013, Vol. 14, Issue 1.
  5. Ansari N, Khodagholi F. Natural Products as Promising Drug Candidates for the Treatment of Alzheimer's Disease: Molecular Mechanism Aspect. CURRENT NEUROPHARMACOLOGY. Bentham Science Publishers. 2013, Vol. 11, Issue 4. DOI: 10.2174/1570159X11311040005
  6. Khodagholi F, Tusi SK, Alamdary SZ, Amini M, Ansari N. 3-Thiomethyl-5,6-(dimethoxyphenyl)-1,2,4-triazine improves neurite outgrowth and modulates MAPK phosphorylation and HSPs expression in H2O2-exposed PC12 cells. TOXICOLOGY IN VITRO. Pergamon-Elsevier Science. 2012, Vol. 26, Issue 6. DOI: 10.1016/j.tiv.2012.04.015
  7. Ashabi G, Ramin M, Azizi P, Taslimi Z, Alamdary SZ, Haghparast A, Ansari N, Motamedi F, Khodagholi F. ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats.. Behav Brain Res. 2012, Vol. 232, Issue 1. DOI: 10.1016/j.bbr.2012.04.006
  8. Khodagholi F, Ansari N, Amini M, Tusi SK. Involvement of molecular chaperones and the transcription factor Nrf2 in neuroprotection mediated by para-substituted-4,5-diaryl-3-thiomethyl-1,2,4-triazines. CELL STRESS & CHAPERONES. Cell Stress Society International. 2012, Vol. 17, Issue 4. DOI: 10.1007/s12192-011-0316-0
  9. Alamdary SZ, Khodagholi F, Shaerzadeh F, Ansari N, Sonboli A, Tusi SK. S. choloroleuca, S. mirzayanii and S. santolinifolia protect PC12 cells from H2O2-induced apoptosis by blocking the intrinsic pathway. CYTOTECHNOLOGY. Springer. 2012, Vol. 64, Issue 4. DOI: 10.1007/s10616-011-9418-x
  10. Ansari N, Khodagholi F, Amini M. 2-Ethoxy-4,5-diphenyl-1,3-oxazine-6-one activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. EUROPEAN JOURNAL OF PHARMACOLOGY. Elsevier Science. 2011, Vol. 658, Issue 2-3. DOI: 10.1016/j.ejphar.2011.02.028
  11. Shaerzadeh F, Ahmadiani A, Esmaeili MA, Ansari N, Asadi S, Tusi SK, Sonboli A, Ghahremanzamaneh M, Khodagholi F. Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC12 cells. JOURNAL OF NATURAL MEDICINES. Springer Verlag. 2011, Vol. 65, Issue 3-4. DOI: 10.1007/s11418-011-0519-9
  12. Ansari N, Khodagholi F, Amini M, Shaerzadeh F. Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-κB pathway and regulation of cellular redox status by an oxazine derivative.. Biochimie. 2011, Vol. 93, Issue 5. DOI: 10.1016/j.biochi.2011.01.012
  13. Farimani MM, Sarvestani NN, Ansari N, Khodagholi F. Calycopterin Promotes Survival and Outgrowth of Neuron-Like PC12 Cells by Attenuation of Oxidative- and ER-Stress-Induced Apoptosis along with Inflammatory Response. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society. 2011, Vol. 24, Issue 12. DOI: 10.1021/tx200420a
  14. Asadi S, Khodagholi F, Esmaeili MA, Tusi SK, Ansari N, Shaerzadeh F, Sonboli A, Ghahremanzamaneh M. Chemical Composition Analysis, Antioxidant, Antiglycating Activities and Neuroprotective Effects of S. choloroleuca, S. mirzayanii and S. santolinifolia from Iran. AMERICAN JOURNAL OF CHINESE MEDICINE. World Scientific Publishing Co. 2011, Vol. 39, Issue 3. DOI: 10.1142/S0192415X1100907X
  15. Joodi G, Ansari N, Khodagholi F. Chitooligosaccharide-mediated neuroprotection is associated with modulation of Hsps expression and reduction of MAPK phosphorylation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. Elsevier Science. 2011, Vol. 48, Issue 5. DOI: 10.1016/j.ijbiomac.2011.02.011

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile