Dr Vijay Rajagopal

  • Room: Level: 02 Room: 10
  • Building: Mechanical Engineering
  • Campus: Parkville

Research interests

  • Biomedical Engineering
  • Cell Shape (cardiac, cancer, breast)
  • Computational Physiology (cancer, heart, breast)
  • Mechanobiology (cancer metastasis, cell motility, red blood cell)
  • Remodeling (cardiac, red blood cell, cell, tissue)
  • Soft Tissue Mechanics (breast, heart)
  • Synthetic Biology

Personal webpage

https://biomedical.eng.unimelb.edu.au/cell-structure-mechanobiology

Biography

Dr Vijay Rajagopal is a Senior Lecturer at the Department of Biomedical Engineering at the University of Melbourne. He was awarded a PhD in Bioengineering from the Auckland Bioengineering Institute, University of Auckland, NZ in 2007. Dr. Rajagopal received national and international recognition for his contributions to biomechanical modeling of the breast for computer aided tracking of breast tumours at the highly reputed international conference of the Medical Image Computing and Computer Assisted Intervention Society in 2007 as well as the 2008 NZ Young Scientist of the Year Awards. He subsequently focussed his post-doctoral research training to understanding the fundamental physical and chemical mechanisms that regulate cell shape and function. He was awarded a highly competitive award by the Royal Society of New Zealand (Marsden Fast Start, 6% success rate) to develop new methods for computational modeling of heart cell shape, sub-cellular architecture and function. He also gained expertise in microfluidics, cell migration and cytoskeletal mechanics at Massachusetts Institute of Technology and the Singapore-MIT Alliance for Research and Technology. In 2014, Dr. Rajagopal was recruited to the University of Melbourne via the Research at Melbourne Accelerator Program to develop a new research group to increase the University's activities in computational physiology and biology as well as cell mechanobiology. Dr. Rajagopal now leads the Cell Structure and Mechanobiology Group, and is a co-founder of the MSE Mechanobiology Lab in the Parkville Biomedical Precinct. Current research projects include: --- Cardiac cell systems biology and mechanobiology in diseases such as diabetic cardiomyopathy and cardiac hypertrophy --- Computational modelling of cancer cell metastasis --- Red blood cell mechanics and malaria --- Breast tissue mechanics with applications in breast cancer diagnosis --- Single ventricle heart mechanics

Recent publications

  1. Hussain A, Ghosh S, Kalkhoran SB, Hausenloy DJ, Hanssen E, Rajagopal V. An automated workflow for segmenting single adult cardiac cells from large-volume serial block-face scanning electron microscopy data. JOURNAL OF STRUCTURAL BIOLOGY. Elsevier. 2018, Vol. 202, Issue 3. DOI: 10.1016/j.jsb.2018.02.005
  2. Rajagopal V, Holmes WR, Lee V. Computational modeling of single-cell mechanics and cytoskeletal mechanobiology. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE. 2018, Vol. 10, Issue 2. DOI: 10.1002/wsbm.1407
  3. Rajagopal V, Bass G, Ghosh S, Hunt H, Walkers C, Hanssen E, Crampin E, Soeller C. Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. Journal of Visualized Experiments. 2018, Vol. 2018, Issue 134. DOI: 10.3791/56817
  4. Ghosh S, Tran K, Delbridge L, Hickey A, Hanssen E, Crampin E, Rajagopal V. Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture. . 2018. DOI: 10.1101/327254
  5. Ghosh S, Crampin E, Hanssen E, Rajagopal V. A Computational Study of the Role of Mitochondrial Organization on Cardiac Bioenergetics. 2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC). IEEE. 2017. DOI: 10.1109/EMBC.2017.8037413
  6. Hussain A, Hanssen E, Rajagopal V. A Semi-Automated Workflow for Segmenting Contents of Single Cardiac Cells from Serial-Block-Face Scanning Electron Microscopy Data. Microscopy and Microanalysis. Cambridge University Press. 2017, Vol. 23, Issue S1. DOI: 10.1017/S143192761700188X
  7. Jarosz J, Ghosh S, Delbridge L, Petzer A, Hickey AJR, Crampin E, Hanssen E, Rajagopal V. Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. American Physiological Society. 2017, Vol. 312, Issue 2. DOI: 10.1152/ajpcell.00298.2016
  8. Lelliott PM, Huang HM, Dixon M, Namvar A, Blanch A, Rajagopal V, Tilley L, Coban C, McMorran BJ, Foote SJ, Burgio G. Erythrocyte beta spectrin can be genetically targeted to protect mice from malaria. BLOOD ADVANCES. American Society of Hematology. 2017, Vol. 1, Issue 26. DOI: 10.1182/bloodadvances.2017009274
  9. Wang ZJ, Wang VY, Babarenda Gamage TP, Rajagopal V, Cao JJ, Nielsen PMF, Bradley CP, Young AA, Nash MP. Principal Component Analysis used to Derive Patient-Specific Load-Free Geometry and Estimate Myocardial Stiffness in the Heart. Computational and Mathematical Biomedical Engineering. 2017.
  10. Rajagopal V, Bass G, Walker CG, Crossman DJ, Petzer A, Hickey A, Siekmann I, Hoshijima M, Ellisman MH, Crampin E, Soeller C. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes. PLOS COMPUTATIONAL BIOLOGY. Public Library of Science. 2015, Vol. 11, Issue 9. DOI: 10.1371/journal.pcbi.1004417
  11. Hou Y, Crossman DJ, Rajagopal V, Baddeley D, Jayasinghe I, Soeller C. Super-resolution fluorescence imaging to study cardiac biophysics: alpha-actinin distribution and Z-disk topologies in optically thick cardiac tissue slices. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. Pergamon. 2014, Vol. 115, Issue 2-3. DOI: 10.1016/j.pbiomolbio.2014.07.003
  12. Lee AWC, Rajagopal V, Gamage TPB, Doyle AJ, Nielsen PMF, Nash MP. Breast lesion co-localisation between X-ray and MR images using finite element modelling. Medical Image Analysis. Elsevier Science. 2013, Vol. 17, Issue 8. DOI: 10.1016/j.media.2013.05.011
  13. Gamage TPB, Boyes R, Rajagopal V, Nielsen PMF, Nash MP. Modelling Prone to Supine Breast Deformation Under Gravity Loading Using Heterogeneous Finite Element Models. Computational Biomechanics for Medicine. Springer. 2012. Editors: Nielsen PMF, Wittek A, Miller K. DOI: 10.1007/978-1-4614-3172-5_5
  14. Rajagopal V, Khwaounjoo P, Walker CG, O'Sullivan M, Soeller C. Subcellular Structural Changes in Diabetic Cardiomyopathy and its Impact on Cardiac Cell Calcium Dynamics. 56th Annual Meeting of the Biophysical-Society. Biophysical Society. 2012, Vol. 102, Issue 3. DOI: 10.1016/j.bpj.2011.11.584
  15. Yan J, Walker CG, O'Sullivan MJ, Bushong EA, Ellisman MH, Hoshijima M, Rajagopal V. Visualization, Modeling, and Spatial Statistics of Mitochondrial Assembly in Adult Cardiomyocytes using Serial Block-Face Scanning Electron Microscopy. 56th Annual Meeting of the Biophysical-Society. Biophysical Society. 2012, Vol. 102, Issue 3. DOI: 10.1016/j.bpj.2011.11.780

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile