Quantitative morphometric analysis (QMA) and image processing

Quantitative Morphometric Analysis uses high-resolution image data to extract measurements of clinical or preclinical importance. These may be healthy and diseased structures of specific importance to the system being studied; for example, small animal joints (30, 33) for drug discovery, human clinical trials (35–38), or disease investigation (27).


38. K. S. Stok, S. Finzel, A. J. Burghardt, P. G. Conaghan, C.  Barnabe. The SPECTRA Collaboration (Study grouP for xtrEme-Computed  Tomography in Rheumatoid Arthritis) OMERACT Special Interest Group –  Current Research and Future Directions, J Rheum, 44, 2017.

37. S. Tom, M. Frayne, S. L. Manske, A. J. Burghardt, K. S. Stok, S.  K. Boyd, and C. Barnabe, Determining Metacarpophalangeal Flexion Angle  Tolerance for Reliable Volumetric Joint Space Measurements by High  Resolution Peripheral Quantitative Computed Tomography (HR-pQCT), J  Rheum, 43:1941-44, 2016.

36. C. Barnabe, D. Toepfer, H. Marotte, E.M. Hauge, A. Scharmga, R.  Kocijan, S. Kraus, S. Boutroy, K. Karup Keller, J. de Jong, J. Williams,  K. S. Stok, S. Finzel, Definition for Rheumatoid Arthritis Erosions  Imaged with High Resolution Peripheral Quantitative Computed Tomography  and Inter-Reader Reliability for Detection and Measurement, J Rheum,  43:1935-40, 2016.

35. S. Nagaraj, S. Finzel, K.S. Stok, C. Barnabe and the SPECTRA  Collaboration, High-Resolution peripheral Quantitative Computed  Tomography (HR-pQCT) Imaging in the Assessment of Periarticular Bone of  Metacarpophalangeal and Wrist Joints, J Rheum, 43:1921-34, 2016.

33. K. S. Stok, B. A. Besler, T. H. Steiner, A. V. Villarreal  Escudero, M. A. Zulliger, M. Wilke, K. Atal, A. Quintin, B. Koller, R.  Müller and D. Nesic. Three-dimensional quantitative morphometric  analysis (QMA) for in situ joint and tissue assessment of osteoarthritis  in a preclinical rabbit disease model, PLoS One, 11(1): e0147564, 2016.

27. D. J. Pawson, M. Glanzmann, R. Lüchinger, R. Müller, K. S. Stok,  Quantitative morphometric patterns in cartilage and bone from the  humeral heads of end-stage osteoarthritis patients. Osteoarthr  Cartilage, 23:1377-1387, 2015.